Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
The annual national civil service exam kicked off last Sunday, and some recent hot topics - such as college graduates starting their own businesses and the Yutu (Jade Rabbit) lunar rover - appeared in the exam questions.
《发生什么了，西蒙妮小姐?》(What Happened, Miss Simone?)，导演：利兹·加布斯(Liz Garbus)。
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
While still on stage, Beatty blamed the epic mishap on being given the wrong envelope, saying he had seen the name Emma Stone from 'La La Land' when he opened his envelope.
Such claims are unlikely to go away, though. John R. Christy, an atmospheric scientist at the University of Alabama in Huntsville who is known for his skepticism about the seriousness of global warming, pointed out in an interview that 2014 had surpassed the other record-warm years by only a few hundredths of a degree, well within the error margin of global temperature measurements. “Since the end of the 20th century, the temperature hasn’t done much,” Dr. Christy said. “It’s on this kind of warmish plateau.”
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Trends and targets in antiviral phototherapy
“This growth is further backed by Video Editing making an appearance at number 3 on the list with a 19% increase,” the report states, “as video content becomes one of the initial draws and call to actions for most customer-focused websites. Heavy video marketing through social media also increases this demand.”
Lady Gaga, who started her own non-profit, the Born This Way Foundation, followed at fourth.
Leatrice Eiseman, the executive director of the Pantone Color Institute, said the joining of the two colors reflected “a soothing sense of order and peace” — presumably an attractive thing to incorporate into a product at a time of insecurity and global turbulence. It also implies that there is no line between “us” and “them.”
For the New Yorkers who have turned their apartments into bed-and-breakfasts, the battle over illegal inns could reach a fever pitch. On top of it all, Mayor Bill de Blasio’s 10-year affordable housing plan will take shape just as legislation in Albany threatens to strain the pocketbooks of renters. These are among the game-changers looming as we ring in the New Year.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Well, what you do makes me cry at night. You grown ups say you love us. I challenge you, please make your actions reflect your words. Thank you for listening. 然而，你们所做的事让我在夜晚哭泣，你们成年人说你们爱我们，我不会再相信了，因为只有行动和语言的合一，才是找回信任和未来的唯一方法！谢谢！
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
“When I started in this business, Brooklyn was the alternative. Now it is a choice,” said Diane M. Ramirez, the chief executive of Halstead Property. “I see Queens becoming that way. The Bronx is not that far down the line.”
ACE2 as a potential therapeutic target for pandemic COVID-19
There are few chief executive decisions that drew more attention this year than Yahoo(YHOO, Fortune 500) CEO Marissa Mayer's work-from-home ban. The policy was initially seen as highly controversial and had a lot of people upset because of its perceived lack of flexibility.
Diagnostic technologies for COVID-19: a review
The 16-year-old surnamed Zhou on April 24 poured pesticide into the water dispenser in the classroom, apparently in an act of revenge against classmates who disturbed the class and affected Zhou's studies, the Chongqing Morning Post said.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
The Big Sick
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
5. Google Webmaster Tools.
Influenza neuraminidase: A druggable target for natural products
Americans: While you're here, why not pretend to be Canadian? Very few Britons can tell the difference, and it will allow you to rescue yourself from awkward conversations about the death penalty.
They will get more creative in 2018, including on non-cash benefits. Bank of America, for example, has just introduced a programme allowing employees of the global banking and markets unit to take a sabbatical — on full pay — for up to six weeks in a year. There are conditions: people must have been with the bank for at least a decade, and can request the time once every five years, to a maximum of three. But in a memo circulated this week, seen by the Financial Times, chief operating officer Tom Montag urged eligible employees to consider it.
The Southwestern African country owns over 20 national parks and has the world's oldest deserts.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The year’s most compelling makeup and hair designs have been almost characters themselves (and are certainly more dynamic than some of those who appear on-screen). But while physical features are obvious right away, they can also give shape and nuance to the performances of those who assume them. Sometimes, a big nose creates a window of understanding.
The role of biosensors in the detection of emerging infectious diseases
This year's best midseason trade action happened early:
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
"Overall this ranking of Asia's best 300 universities proves what a dynamic, diverse and competitive higher education region the continent is becoming -- and China is a key part of that development," said Baty.
I used to think guff was a product of failure and mediocrity — it existed because the truth was too painful, or because executives had not bothered to ascertain what the truth was.
Adriana Lima sizzled in red, while Alessandra Ambrosio looked amazing just months after giving birth.
I can well imagine that in 2016 the oil price will bounce back from its current sub $40 level. The Saudis may try to cut production, there could be more conflict in Iraq, terrorists could attack some of the prize targets such as the oil terminals at Ras Tanura and Abqaiq. Anything is possible, something is likely. But the question is how far the bounce will go.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The government-sponsored students have signed an agreement that says they are required to reimburse the government if they do not return home after completing their studies, said Xiong Binqi, vice president of 21st Century Education Research Institute.
Faster growth should also dispel worries about another Fed bogeyman: deflation, or falling prices. "It's impossible to have deflation in an economy growing 3%-plus and adding the most jobs since the 1990s," Baumohl said.
Both the film and the television series are adapted from the Taiwan action role-playing game of the same name which was developed by Softstar Entertainment. The game is considered by many as simply one of the best Chinese RPG's ever created.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Meanwhile, the University of Bradford School of Management and the University of Edinburgh Business School each climb 16 places, to 42nd and 55th, respectively. Judge Business School at the University of Cambridge rises 15 places to 14th.
Inhibition of SARS coronavirus helicase by bismuth complexes
在苹果今年6月举行的全球开发者大会(Worldwide Developer Conference)上，库克被应用开发者团团围住，要求与他自拍合影。到了10月的iPad发布会，他甚至自己讲起了笑话。他还是一贯的着装，简单朴实：黑衬衫，牛仔裤，衬衫下摆散着。他说，Apple Watch得到了“深谙时尚与风格——比我还懂的人”的热烈好评，一边说，一边心照不宣地指着轻声发笑的观众。
n. 史诗，叙事诗 adj. 史诗的，叙事诗的，宏大的，
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
They are calculated using a methodology that focuses on a school's research performance and reputation, not its specific undergraduate or graduate programs. This is a separate methodology than those used for other US News rankings such as Best Colleges and Best Graduate Schools.
“An employee stormed out in the middle of a meeting, without explanation.”
Soyabeans which are trading above $10 a bushel are expected to remain strong, while dairy prices are also expected to rise during 2017 as demand steadily increases, said the bank.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
After working for half a year, the average monthly income for 2014 graduates is RMB3,487, a significant increase from RMB3,250 in 2013 and RMB3,048 in 2012.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
The letter mysteriously arrived at the California University of Pennsylvania, in the north-eastern state of Pennsylvania, 10 days ago. Written to Mr Moore, the two-page letter was postmarked 20 February 1958 and signed "love forever Vonnie".
Caleb Rogers is one of two people facing legal action from gaming studio Epic Games for using cheat software to play the game Fortnite.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
This is not to take anything away from Tesla, which has demonstrated that it can create and manufacture a complex and sophisticated product with demonstrated customer appeal. But its own internal forecasts, as well as the swelling of its share price, are based on the expectation that the future will unspool in an orderly fashion identical to the recent past. That’s a dangerous assumption to make – for several reasons:
No.2: Another Reason for Staying in Bed
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
你可能觉得我们对于列清单的爱好是从“十诫”继承而来，但安伯托·艾柯( Umberto Eco)的说法却正相反，“清单是文化的起源”，他写过一本书，《无限的清单》(The Infinity of Lists)，书中在讨论自己熟悉的东西时这样说道。而且，文化希望“让无限变得可以理解”，并且“创造秩序——不是永远如此，但通常都是这样”，所以才有了荷马在《伊利亚特》中的人名清单，以及你冰箱上贴着的，永远做不完的家务清单。“我们喜欢清单，因为我们不想死，”艾柯还说，这可能是对“清单体”(listicle)的最佳解释了。
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Likewise, if the 11 countries led by Japan left in the TPP manage to salvage a deal following the US exit that could provide some balance in the region.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
smiles and puma snarls
Yes. In 2018 President Trump will deliver on some of his protectionist campaign rhetoric by taking punitive actions against China. The most likely triggers for action will be official reports that the Trump administration has commissioned into China’s alleged theft of intellectual property, and its subsidised production of steel and aluminium. The president, spurred on by his trade team, is likely to order retaliatory measures, including tariffs. Whether that marks the first shot in a trade war will depend on how China reacts. A Chinese decision to impose retaliatory tariffs, or to take America to the World Trade Organization, will signal the opening of hostilities.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
9. “The Big Short” Adam McKay plays it for comedy, but as he carpet-bombs the screen with laughs, he makes it clear that his take on the 2008 economic meltdown is a staggering American tragedy.
Fortunately, the rules are changing. The proposal of China's Central Economic Conference in early December to give rural residents permanent urban residency sent a strong signal. Premier Wen Jiabao's call in late December for the reform of the household registration system will surely speed up the process.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
There are always one or two coworkers in the office that most people can't stand. But if you don't like most of your coworkers, chances are your days aren't very enjoyable because you have to work with them day in and day out. If you can't stand most of your coworkers, it's time to think about finding a company whose employees you mesh with better.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
These artificial ears will be a huge benefit to those who suffer injuries or who have microtia, a condition that keeps the ears from ever developing.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Moreover, a “turnaround in the short run is unlikely”, given China’s efforts to rebalance its economy from exports towards consumption (thereby reducing demand for imports of intermediate inputs), reinforced by “government policy to stimulate the use of domestic suppliers” and rising protectionism elsewhere, he argues.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
The global survey was conducted between 2010 and 2012 and follows the Earth Institute's first rankings released last year. While "the world has become a slightly happier and more generous place over the past five years," economic and political upheavals have resulted in greatly reduced levels of well being for some nations, the report said.
In the past five years, China's exports of goods grew at an annual average of 6.5 percent, with its share in the global market rising form 10.4 percent in 2010 to about 13.2 percent in 2015, faring much better than major global economies. Service trade grew over 13.6 percent each year, marking the world's second largest service trader.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
2010 S&P 500 index (year-end): 1300
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
The Big Bang Theory is not short on geniuses. Not only is the show about highly intelligent scientists, but cast member Mayim Bialik has a Ph.D. in Neuroscience. So it should come as no surprise that the cast would want to show off their intelligence and attention to detail. In Sheldon and Leonard's apartment, there's a large white board. The two roommates use the board frequently for everything from actual work that Leonard or Sheldon has brought home, or to decide whether to eat before or after the new Spider-Man movie.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
The top SUV maker and MPV maker last month are familiar to all: Great Wall Motor and SAIC General Motor Wuling stayed on their segment thrones. SAIC Volkswagen also maintained its crown in the sedans and hatchbacks segment.
A modular microarray imaging system for highly specific COVID-19 antibody testing
As of mid-July, there were about 50,000 stores running on Bigcommerce, which have collectively sold close to $4 billon using the platform. The developer has typically added new customers one-by-one. However, a deal it struck in early July with eBay positions its service as the preferred migration path for two Magento products that will be discontinued in February 2015, Go and ProStores. Bigcommerce previously migrated more than 5,000 merchants off ProStores, and the deal could potentially bring up to 10,000 more.
These are the major winners of the 68th annual Primetime Emmy Awards. Additional winners are listed at emmys.com.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
When contraband goods made from prohibited wildlife are seized in the United States, they find their way to the National Wildlife Property Repository near Denver. Pictures taken by Tristan Spinski from inside the facility — shoes made of leopard skin, a lamp made with zebra hooves, a sea turtle’s skull, an elephant foot stool — “testify to the human appetite for other species,” Rachel Nuwer wrote for The Times in July.
6. Cancer Mortality Rate
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Second, McDermott, a career 39.9% three-point shooter, addresses Oklahoma City's biggest roster weakness—a lack of perimeter options around Russell Westbrook—and remains on a bargain rookie deal through the end of next season.
Ranked 10th position, Industrial and Commercial Bank of China is the highest ranking Chinese company on the list.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
In this Jan. 15, 2008, file photo, Apple CEO Steve Jobs holds up the new MacBook Air after giving the keynote address at the Apple MacWorld Conference in San Francisco
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Denmark, Norway, Switzerland, the Netherlands and Sweden are the world's happiest countries, according to the survey of 156 countries. Rwanda, Burundi, the Central African Republic, Benin and Togo -- all nations in Sub-Saharan Africa -- are the least satisfied with their lives, the report said. China ranks 93rd in the list.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
So ladies, we have been warned. What would your response be?
Nepal remains a fabulous choice for budget-conscious travelers, whether it's the country's world-famous trekking routes or the wildlife in the southern region. Travel costs per day are as low as $50 on average.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Despite the reported success of the Duke and Duchess of Cambridge's official visit to Canada back in September, timekeeping needs to be looked at for future trips.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
HSBC economist Hongbin Qu said the survey pointed to lost momentum in China's manufacturing sector: He expects Beijing to respond with measures to counteract the slowdown.
Writing for a Comedy Series: Aziz Ansari and Alan Yang, “Master of None” (“Parents”)
倡导“女权主义外交政策”的瑞典外交部长玛戈特·瓦尔斯特伦(Margot Wallstrom)向埃伦·巴里(Ellen Barry)敞开心扉，回忆了自己年轻时被当时的男友虐待的经历。她以前从未公开说过此事。
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
12) I often find myself worrying about something 0 1 2 3 4
The UK’s Warwick Business School recorded the best progression at the top, moving up from 16th to ninth place, while the Shanghai Advanced Institute of Finance (Saif), based at JiaoTong University, enjoys the bestprogression overall, jumping from 28th to 14th place.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
《纸牌屋》(House of Cards)，Netflix，2月27日播出。Netflix的政治大戏，第三季有13集。除凯文·斯派西(Kevin Spacey)与罗宾·怀特(Robin Wright)外，曾出演《忧愁河上桥》(Treme)的基姆·迪金斯(Kim Dickens)亦加盟该剧，“Pussy Riot”的两位成员亦有客座出演。
The data measure how successful alumni have been in their career in terms of salary, seniority and achievements since graduating.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Tongzhou was designated as the site of a new administrative center for the municipal government to help relieve the current heavy pressure on public services in downtown Beijing, where the central government is located.
Ahead of the release, economists at ANZ said they expected inflation to pick up in January owing to rising food prices, and the low commodity prices would weigh on the CPI.
Length-scale dependence of protein hydration-shell density
Emma Thompson, a two-time winner for Howards End and Sense and Sensibility, famously keeps hers in the loo: “They look far too outré anywhere else. They’re great big, gold, shiny things.” She’s not alone – Susan Sarandon, Lionel Richie and Sean Connery all claim to keep their golden fellas alongside their bidets and baths.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A powerful earthquake struck off Japan's southern coast on May 30, prompting fears in China of a catastrophe similar to the tsunami and Fukushima nuclear power plant meltdown that followed the 2011 Japanese quake. In the end, no fatalities or major damage were reported.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
The Shanghai Composite is nursing a decline of 6.85 per cent, while the tech-focused Shenzhen Composite is down 8.19 per cent.
About this collection
WTF.2: They Believe You Can Fly
Inspired by this, researchers and scientists have been working on areas where making things small may mean big results.