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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

The annual national civil service exam kicked off last Sunday, and some recent hot topics - such as college graduates starting their own businesses and the Yutu (Jade Rabbit) lunar rover - appeared in the exam questions.
《发生什么了,西蒙妮小姐?》(What Happened, Miss Simone?),导演:利兹·加布斯(Liz Garbus)。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

While still on stage, Beatty blamed the epic mishap on being given the wrong envelope, saying he had seen the name Emma Stone from 'La La Land' when he opened his envelope.
Such claims are unlikely to go away, though. John R. Christy, an atmospheric scientist at the University of Alabama in Huntsville who is known for his skepticism about the seriousness of global warming, pointed out in an interview that 2014 had surpassed the other record-warm years by only a few hundredths of a degree, well within the error margin of global temperature measurements. “Since the end of the 20th century, the temperature hasn’t done much,” Dr. Christy said. “It’s on this kind of warmish plateau.”

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

自从这家技术公司十年前开始发布这一年度报告以来,这是新闻首次成为最热门的搜索项。搜狐资深编辑兼网络趋势分析师陈女士(Vera Chan)说,出于各种原因,英国石油公司漏油事件成为了最热门的搜索话题。

Graphical abstract: Soft matter science and the COVID-19 pandemic
From the themed collection: 农地改革开启多策联动模式
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

沙特阿美(Saudi Aramco)会在外国公开上市吗?

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

n. 暴行,侮辱,愤怒
认真思考一下:未来的经历能提高你的知识和技能吗?它是否会让你接触到新的观点,认识不同的人?(这些都是支持你对机会说“Yes”的好理由!)你需要为了管理团队或与经验更加丰富的同事共事而培养新技巧吗?如果答案是肯定的,那就接受这种挑战,走出你的舒适区。
对于很多西方白人来说,取得“获得性身份认同”(登上山巅)的机会似乎已经变得遥不可及。所以“先赋性身份认同”——也就是他们的“白”——变得比以往更加重要起来。
['v?:tju:]

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

“This growth is further backed by Video Editing making an appearance at number 3 on the list with a 19% increase,” the report states, “as video content becomes one of the initial draws and call to actions for most customer-focused websites. Heavy video marketing through social media also increases this demand.”
Lady Gaga, who started her own non-profit, the Born This Way Foundation, followed at fourth.
Leatrice Eiseman, the executive director of the Pantone Color Institute, said the joining of the two colors reflected “a soothing sense of order and peace” — presumably an attractive thing to incorporate into a product at a time of insecurity and global turbulence. It also implies that there is no line between “us” and “them.”
For the New Yorkers who have turned their apartments into bed-and-breakfasts, the battle over illegal inns could reach a fever pitch. On top of it all, Mayor Bill de Blasio’s 10-year affordable housing plan will take shape just as legislation in Albany threatens to strain the pocketbooks of renters. These are among the game-changers looming as we ring in the New Year.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Well, what you do makes me cry at night. You grown ups say you love us. I challenge you, please make your actions reflect your words. Thank you for listening. 然而,你们所做的事让我在夜晚哭泣,你们成年人说你们爱我们,我不会再相信了,因为只有行动和语言的合一,才是找回信任和未来的唯一方法!谢谢!

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

据高部长称,在“十三五”计划期间,中国在与“一带一路”的国家形成优势互补的跨国产业链、价值链的同时,还将持续大力改善投资环境,充分挖掘市场潜力。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

补救办法:这也是一个后知后觉的遗憾,没有时间机器是无法解决的。你在学业上花费的时间、精力和金钱是既定成本。你无法改变以前的学业情况,但可以找出自己在大学期间没有学好的课程,然后想办法从现在开始弥补。例如,如果你觉得自己在课堂外的社交有所不足,你可以考虑加入校友协会,或者努力地融入到你所在领域的行业协会。如果你后悔错过了早上八点钟的管理会计课程,悲叹这些知识现在对你多么重要,那么你可以看看附近社区大学的这类课程。
“When I started in this business, Brooklyn was the alternative. Now it is a choice,” said Diane M. Ramirez, the chief executive of Halstead Property. “I see Queens becoming that way. The Bronx is not that far down the line.”

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
From the themed collection: 沈阳成高端家居消费制高点
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

这种增长为中国电影业未来的发展奠定了坚实的基础。
There are few chief executive decisions that drew more attention this year than Yahoo(YHOO, Fortune 500) CEO Marissa Mayer's work-from-home ban. The policy was initially seen as highly controversial and had a lot of people upset because of its perceived lack of flexibility.

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

原指拍film用的film(n 胶卷)-轻而薄且不牢固的
The 16-year-old surnamed Zhou on April 24 poured pesticide into the water dispenser in the classroom, apparently in an act of revenge against classmates who disturbed the class and affected Zhou's studies, the Chongqing Morning Post said.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

(可可英语版权所有,未经允许请勿转载)
['epis?ud]
内战发生在奥创事件之后。那时,政府决定超级英雄们必须在政府管理下行事,不能再单独行动。“美国队长”斯蒂夫·罗杰斯表示反对,但“钢铁侠”托尼·斯塔克却赞成政府的做法。两人之间的冲突因此形成。
The Big Sick

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

只剩下空洞的形式。所以,借鉴这些熟悉的形式看似稳妥,实际上并非如此。它是空洞的,可以被丢弃,所以,60年代的风格一直被认为是一股“潮流”——“潮流”暗含的意思是,在某一时刻它将“终结”。虽然“终结”尚未到来。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

澳大利亚管理研究生院的一名毕业生表示:“最初,我对攻读在线课程颇有疑虑,但沟通和在线互动非常棒。”
成千上万在外求学的人或者在外工作的人都会在春节临近时回家团圆。这个传统是造成春运压力的主要原因。另外一个原因就是春节正好是中国两大黄金周之一,是许多人旅游的好时机。春运一般从节前15天开始到节后25天结束。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
From the themed collection: 建筑卫生陶瓷产业急需转型升级
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

funds

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 北京54.79亿元扶贫资金拨付到位
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

但是,海外机构投资者表示,随着中国经济增长放慢,香港房地产市场已经过热,正在进入调整阶段。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

截止发稿时为止,在中国社交媒体上仍然能够找到一些被泄露的照片和视频。
5. Google Webmaster Tools.
一些最近发表的科学论文说,高空急流中这种持续较长的怪现象,由于全球变暖正在导致北极地区海洋中的冰迅速融化而变得更可能发生,但许多主要的科学家还没有被这种观点说服。
最近几年,中国赴韩旅游出现了蓬勃发展,这让韩国的零售商高兴不已,不过也激怒了韩国国内的游客,因为他们发现韩国旅游景点被来访游客淹没。

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

贝拉是该榜单上最年轻的模特,她上个月刚满21岁。
Americans: While you're here, why not pretend to be Canadian? Very few Britons can tell the difference, and it will allow you to rescue yourself from awkward conversations about the death penalty.
在周五晚上,金州勇士队以106比94击败了芝加哥公牛队,将战绩提升为14胜0负。库里本场比赛拿下27分,而卫冕冠军也距离NBA历史最佳开局纪录只有一场之遥。
They will get more creative in 2018, including on non-cash benefits. Bank of America, for example, has just introduced a programme allowing employees of the global banking and markets unit to take a sabbatical — on full pay — for up to six weeks in a year. There are conditions: people must have been with the bank for at least a decade, and can request the time once every five years, to a maximum of three. But in a memo circulated this week, seen by the Financial Times, chief operating officer Tom Montag urged eligible employees to consider it.
The Southwestern African country owns over 20 national parks and has the world's oldest deserts.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

The year’s most compelling makeup and hair designs have been almost characters themselves (and are certainly more dynamic than some of those who appear on-screen). But while physical features are obvious right away, they can also give shape and nuance to the performances of those who assume them. Sometimes, a big nose creates a window of understanding.
Hurricane Irma

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

This year's best midseason trade action happened early:

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

科学家周日表示,2013年,全球温室气体排放量增加了2.3%,达到历史新高。这个最新迹象表明,在控制全球变暖方面,国际社会的努力仍远远不够。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 租户人身安全亟须立法明确保障
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

"Overall this ranking of Asia's best 300 universities proves what a dynamic, diverse and competitive higher education region the continent is becoming -- and China is a key part of that development," said Baty.
I used to think guff was a product of failure and mediocrity — it existed because the truth was too painful, or because executives had not bothered to ascertain what the truth was.
Adriana Lima sizzled in red, while Alessandra Ambrosio looked amazing just months after giving birth.
I can well imagine that in 2016 the oil price will bounce back from its current sub $40 level. The Saudis may try to cut production, there could be more conflict in Iraq, terrorists could attack some of the prize targets such as the oil terminals at Ras Tanura and Abqaiq. Anything is possible, something is likely. But the question is how far the bounce will go.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

The government-sponsored students have signed an agreement that says they are required to reimburse the government if they do not return home after completing their studies, said Xiong Binqi, vice president of 21st Century Education Research Institute.
Faster growth should also dispel worries about another Fed bogeyman: deflation, or falling prices. "It's impossible to have deflation in an economy growing 3%-plus and adding the most jobs since the 1990s," Baumohl said.
Both the film and the television series are adapted from the Taiwan action role-playing game of the same name which was developed by Softstar Entertainment. The game is considered by many as simply one of the best Chinese RPG's ever created.
中央财政拿了1000亿元专项资金用于员工转岗安置,并且要求地方政府配套。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
From the themed collection: 2015年家居市场前三季度市场比较
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

你可以在AskMen.com网站上看到完整榜单。以下是最性感女人前十名:
Meanwhile, the University of Bradford School of Management and the University of Edinburgh Business School each climb 16 places, to 42nd and 55th, respectively. Judge Business School at the University of Cambridge rises 15 places to 14th.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

Thor: Ragnarok
萨姆·史密斯是一个风格多变的男人,他可以在奥蒂斯·雷丁、艾瑞莎·弗兰克林和雷·查尔斯以及像艾米·怀恩豪斯和阿黛尔这样的现代偶像的风格中随意转换。
在苹果今年6月举行的全球开发者大会(Worldwide Developer Conference)上,库克被应用开发者团团围住,要求与他自拍合影。到了10月的iPad发布会,他甚至自己讲起了笑话。他还是一贯的着装,简单朴实:黑衬衫,牛仔裤,衬衫下摆散着。他说,Apple Watch得到了“深谙时尚与风格——比我还懂的人”的热烈好评,一边说,一边心照不宣地指着轻声发笑的观众。
n. 史诗,叙事诗 adj. 史诗的,叙事诗的,宏大的,
n. 谈话,演讲

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
From the themed collection: 南海如何进一步吸引大学生?
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

They are calculated using a methodology that focuses on a school's research performance and reputation, not its specific undergraduate or graduate programs. This is a separate methodology than those used for other US News rankings such as Best Colleges and Best Graduate Schools.
“An employee stormed out in the middle of a meeting, without explanation.”
Soyabeans which are trading above $10 a bushel are expected to remain strong, while dairy prices are also expected to rise during 2017 as demand steadily increases, said the bank.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

[?m'fibi?s]
After working for half a year, the average monthly income for 2014 graduates is RMB3,487, a significant increase from RMB3,250 in 2013 and RMB3,048 in 2012.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
From the themed collection: 北京通州启动群租房专项治理
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
From the themed collection: 不要迷信房地产对经济拉动作用
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

The letter mysteriously arrived at the California University of Pennsylvania, in the north-eastern state of Pennsylvania, 10 days ago. Written to Mr Moore, the two-page letter was postmarked 20 February 1958 and signed "love forever Vonnie".
8qFVdkcH4D(jz2U^
Caleb Rogers is one of two people facing legal action from gaming studio Epic Games for using cheat software to play the game Fortnite.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

This is not to take anything away from Tesla, which has demonstrated that it can create and manufacture a complex and sophisticated product with demonstrated customer appeal. But its own internal forecasts, as well as the swelling of its share price, are based on the expectation that the future will unspool in an orderly fashion identical to the recent past. That’s a dangerous assumption to make – for several reasons:
reform
No.2: Another Reason for Staying in Bed

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

你可能觉得我们对于列清单的爱好是从“十诫”继承而来,但安伯托·艾柯( Umberto Eco)的说法却正相反,“清单是文化的起源”,他写过一本书,《无限的清单》(The Infinity of Lists),书中在讨论自己熟悉的东西时这样说道。而且,文化希望“让无限变得可以理解”,并且“创造秩序——不是永远如此,但通常都是这样”,所以才有了荷马在《伊利亚特》中的人名清单,以及你冰箱上贴着的,永远做不完的家务清单。“我们喜欢清单,因为我们不想死,”艾柯还说,这可能是对“清单体”(listicle)的最佳解释了。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

我们进行一个比较,佳士得和苏富比的这两次18世纪前绘画大师作品拍卖会共拍得2910万英镑,比五年前(2011年12月)类似拍卖会拍得的4420万英镑少了34%。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
From the themed collection: 广东累计缴存公积金超1.5万亿元
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Likewise, if the 11 countries led by Japan left in the TPP manage to salvage a deal following the US exit that could provide some balance in the region.
随着俄罗斯货币卢布一再对其他货币贬值,近年来去往俄罗斯旅游的旅客也在逐渐增多。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

但是,欧洲央行宣布决定后市场暴跌。投资者抱怨称,这家央行此前在其准备注入多少额外刺激以支撑复苏的问题上误导了市场。
corn
smiles and puma snarls
Yes. In 2018 President Trump will deliver on some of his protectionist campaign rhetoric by taking punitive actions against China. The most likely triggers for action will be official reports that the Trump administration has commissioned into China’s alleged theft of intellectual property, and its subsidised production of steel and aluminium. The president, spurred on by his trade team, is likely to order retaliatory measures, including tariffs. Whether that marks the first shot in a trade war will depend on how China reacts. A Chinese decision to impose retaliatory tariffs, or to take America to the World Trade Organization, will signal the opening of hostilities.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

目前全国11个省的52所高校配备了自动售货机,出售艾滋病检测试剂以供学生自查。
单词slew 联想记忆:

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

9. “The Big Short” Adam McKay plays it for comedy, but as he carpet-bombs the screen with laughs, he makes it clear that his take on the 2008 economic meltdown is a staggering American tragedy.
Fortunately, the rules are changing. The proposal of China's Central Economic Conference in early December to give rural residents permanent urban residency sent a strong signal. Premier Wen Jiabao's call in late December for the reform of the household registration system will surely speed up the process.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

There are always one or two coworkers in the office that most people can't stand. But if you don't like most of your coworkers, chances are your days aren't very enjoyable because you have to work with them day in and day out. If you can't stand most of your coworkers, it's time to think about finding a company whose employees you mesh with better.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

政治也对气候的认知有所影响,超过3/4的民主党人和六成独立派人士认为在过去几年中气候越来越极端,而不到半数共和党人认同这种转变。
8月7日
These artificial ears will be a huge benefit to those who suffer injuries or who have microtia, a condition that keeps the ears from ever developing.
“我才17岁——我想留在家人和朋友身边,继续上学,”他说,“在可以预见的未来里,我将留在伦敦。”

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

当然这也并不是说,你害怕老板起疑心,就要放弃你在领英上面的简介。但是告诉你,得小心点。其中一点是关掉你的活动广播这样你每一次策略性的行动就不会被所有网民发现,下面教你怎么做,在主页面,光标停在右上角,点击个性设置,在个性设置里面点击活动广播。
Moreover, a “turnaround in the short run is unlikely”, given China’s efforts to rebalance its economy from exports towards consumption (thereby reducing demand for imports of intermediate inputs), reinforced by “government policy to stimulate the use of domestic suppliers” and rising protectionism elsewhere, he argues.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

The global survey was conducted between 2010 and 2012 and follows the Earth Institute's first rankings released last year. While "the world has become a slightly happier and more generous place over the past five years," economic and political upheavals have resulted in greatly reduced levels of well being for some nations, the report said.
In the past five years, China's exports of goods grew at an annual average of 6.5 percent, with its share in the global market rising form 10.4 percent in 2010 to about 13.2 percent in 2015, faring much better than major global economies. Service trade grew over 13.6 percent each year, marking the world's second largest service trader.
克普克表示,在这些情况下,美联储不但能引发危机,还会增加新兴市场因其他因素引发危机的脆弱性。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

2010 S&P 500 index (year-end): 1300
此外,该报告还指出,雨果博斯、雪佛兰和舒洁则跌出了该榜单。
“听起来,哈佛对学生的私生活管得太宽了”,曾为OJ?辛普森等多位名人做过代理律师的德肖维茨说。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

The Big Bang Theory is not short on geniuses. Not only is the show about highly intelligent scientists, but cast member Mayim Bialik has a Ph.D. in Neuroscience. So it should come as no surprise that the cast would want to show off their intelligence and attention to detail. In Sheldon and Leonard's apartment, there's a large white board. The two roommates use the board frequently for everything from actual work that Leonard or Sheldon has brought home, or to decide whether to eat before or after the new Spider-Man movie.
但是即使在一些糟糕的经济环境下,一些岗位并不是值得一做的。当你在决定是否要放弃的时候,你是不是应该寻找一些迹象呢?这里有10种信号告诉你是否该找一份新的工作呢:

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
From the themed collection: 南京黏土砖瓦窑退出历史舞台
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

The top SUV maker and MPV maker last month are familiar to all: Great Wall Motor and SAIC General Motor Wuling stayed on their segment thrones. SAIC Volkswagen also maintained its crown in the sedans and hatchbacks segment.
但对于北京来说,若能在特朗普让美国退出TPP后不到一年的时间里达成RCEP协议,将是一场巨大的胜利。
私人侦探已进行指控,但是他们表示,不会公布枪击详情,除非两名年轻人周五出庭。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

As of mid-July, there were about 50,000 stores running on Bigcommerce, which have collectively sold close to $4 billon using the platform. The developer has typically added new customers one-by-one. However, a deal it struck in early July with eBay positions its service as the preferred migration path for two Magento products that will be discontinued in February 2015, Go and ProStores. Bigcommerce previously migrated more than 5,000 merchants off ProStores, and the deal could potentially bring up to 10,000 more.
These are the major winners of the 68th annual Primetime Emmy Awards. Additional winners are listed at emmys.com.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

许多人认为韩国流行音乐产业的崛起是这个整容热潮背后的原因,许多人带着明星的照片来到整形医院,要求仿照明星的鼻型或眼睛来整容。
When contraband goods made from prohibited wildlife are seized in the United States, they find their way to the National Wildlife Property Repository near Denver. Pictures taken by Tristan Spinski from inside the facility — shoes made of leopard skin, a lamp made with zebra hooves, a sea turtle’s skull, an elephant foot stool — “testify to the human appetite for other species,” Rachel Nuwer wrote for The Times in July.
6. Cancer Mortality Rate

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

自从在2009年从榜单的第一位落到第五位之后,小甜甜布兰妮的排名继续下滑,随着嘎嘎小姐和贾斯汀 比伯这些新星的走红,布兰妮在2010年仅名列第十位。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Second, McDermott, a career 39.9% three-point shooter, addresses Oklahoma City's biggest roster weakness—a lack of perimeter options around Russell Westbrook—and remains on a bargain rookie deal through the end of next season.
Ranked 10th position, Industrial and Commercial Bank of China is the highest ranking Chinese company on the list.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

In this Jan. 15, 2008, file photo, Apple CEO Steve Jobs holds up the new MacBook Air after giving the keynote address at the Apple MacWorld Conference in San Francisco
经济学家表示,香港住宅市场和商业地产市场都将受到一些相同因素的损害:中国增长放缓、人民币贬值、中国内地反腐以及美国低利率环境将走向终结的预期。然而,住宅市场的发展还受到一个额外因素的阻碍,即2012年政府为减少香港房地产市场上的投机活动而出台的“降温”措施。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 中国经济:信心强 动力足
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

ZnS#k]Z047gSW1juv]
大师级别的老式、线性的动作电影拍摄,充满污秽、朋克、反乌托邦的澳大利亚式幽默。也是最近除玛格丽特·阿斯特伍德(Margaret Atwood)的小说之外,最好的生态-女权-社会主义作品。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

Denmark, Norway, Switzerland, the Netherlands and Sweden are the world's happiest countries, according to the survey of 156 countries. Rwanda, Burundi, the Central African Republic, Benin and Togo -- all nations in Sub-Saharan Africa -- are the least satisfied with their lives, the report said. China ranks 93rd in the list.
这些,都只是纽约人2015年将会遇到的部分问题。而且,邻居家的儿子在圣诞节收到了新的爵士鼓,你又免不了要头疼了……

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
From the themed collection: “光伏大国”蓝图初现
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

5.高效决策者

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

同期,巴西和俄罗斯分别减持到2617亿美元和1089亿美元。
在春运期间,国内的交通运输将面临极大的挑战,车票供小于求。铁路局会采取多种措施来应对春运压力,比如开设临客(L字头的列车)、延长售票时间以及开设更多的售票点。
So ladies, we have been warned. What would your response be?
Nepal remains a fabulous choice for budget-conscious travelers, whether it's the country's world-famous trekking routes or the wildlife in the southern region. Travel costs per day are as low as $50 on average.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

Despite the reported success of the Duke and Duchess of Cambridge's official visit to Canada back in September, timekeeping needs to be looked at for future trips.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

HSBC economist Hongbin Qu said the survey pointed to lost momentum in China's manufacturing sector: He expects Beijing to respond with measures to counteract the slowdown.
Writing for a Comedy Series: Aziz Ansari and Alan Yang, “Master of None” (“Parents”)
倡导“女权主义外交政策”的瑞典外交部长玛戈特·瓦尔斯特伦(Margot Wallstrom)向埃伦·巴里(Ellen Barry)敞开心扉,回忆了自己年轻时被当时的男友虐待的经历。她以前从未公开说过此事。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

12) I often find myself worrying about something 0 1 2 3 4
The UK’s Warwick Business School recorded the best progression at the top, moving up from 16th to ninth place, while the Shanghai Advanced Institute of Finance (Saif), based at JiaoTong University, enjoys the bestprogression overall, jumping from 28th to 14th place.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

《纸牌屋》(House of Cards),Netflix,2月27日播出。Netflix的政治大戏,第三季有13集。除凯文·斯派西(Kevin Spacey)与罗宾·怀特(Robin Wright)外,曾出演《忧愁河上桥》(Treme)的基姆·迪金斯(Kim Dickens)亦加盟该剧,“Pussy Riot”的两位成员亦有客座出演。
The data measure how successful alumni have been in their career in terms of salary, seniority and achievements since graduating.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

圣加伦大学的表现优于上榜的其他商学院,这部分应归功于该校在国际指标上的高分。该校逾90%的学员和80%的教师来自海外。在项目期间学员国际流动性和国际交流方面,圣加伦大学都排名第二。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Tongzhou was designated as the site of a new administrative center for the municipal government to help relieve the current heavy pressure on public services in downtown Beijing, where the central government is located.
Ahead of the release, economists at ANZ said they expected inflation to pick up in January owing to rising food prices, and the low commodity prices would weigh on the CPI.
夏普利对这一主题提出了早期的理论,在20世纪50年代和60年代利用博弈论来分析不同的匹配方式。与美国经济学家大卫?盖尔一起,他开发了一个数学公式10个男人和10个女人如何配对才能保证没有人会受益于配对伙伴。虽然这可能有一点影响到结婚和离婚,他们开发的算法已经被用于更好地理解许多不同的市场。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

这位设计师晚年最重要的伙伴之一就是他的伯曼猫邱佩特,拉格菲尔德称它为他唯一的真爱,而且他还曾说过,如果(与动物结婚)合法的话,他会与邱佩特结婚。
引发收购热议的是一篇路透社的报道,报道援引了一份关于潜在交易的文档作为消息源。实际上,三星已经至少一次地表示过对黑莓的兴趣了,那时还是2012年。而对于最新的谣言,传闻被收购的目标黑莓首先跳出来否认交易正在进行。
2016年,担忧和愤怒主导了英国和美国这两个最重要、稳定、悠久的民主政体的政治情绪。
Emma Thompson, a two-time winner for Howards End and Sense and Sensibility, famously keeps hers in the loo: “They look far too outré anywhere else. They’re great big, gold, shiny things.” She’s not alone – Susan Sarandon, Lionel Richie and Sean Connery all claim to keep their golden fellas alongside their bidets and baths.

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 人民日报:结构性去杠杆稳步推进
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

n. 补给,供给,供应,贮备
A powerful earthquake struck off Japan's southern coast on May 30, prompting fears in China of a catastrophe similar to the tsunami and Fukushima nuclear power plant meltdown that followed the 2011 Japanese quake. In the end, no fatalities or major damage were reported.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

The Shanghai Composite is nursing a decline of 6.85 per cent, while the tech-focused Shenzhen Composite is down 8.19 per cent.
不管个人观点如何,不可否认的是,现在存在着支持和反对俄罗斯全球定位的两种观点:
祝贺佳节。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

WTF.2: They Believe You Can Fly
Inspired by this, researchers and scientists have been working on areas where making things small may mean big results.

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